If you’re looking for a Microsoft Vista defrag replacement, JkDefrag might be worth your consideration…

• Low overhead: it does not place an undue burden on the system;
• Fully automated operation: there are no interactive buttons or menus;
• Command line interface (for scheduled defragmentation, or for use with administrator scripts);
• Screensaver defragmentation, with the option to run another screen saver when done;
• Complete source code (Microsoft Visual C++ 2005) available for download;
• A DLL library (for use in programming) licensed using the LGPL;
• Support for 64 bit versions of Windows XP and Vista.

jkdefrag wiki info
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Another option is Power Defragmenter which offers a GUI for Contig. Contig is a single-file defragmenter that attempts to make files contiguous on disk. Its perfect for quickly optimizing files that are continuously becoming fragmented.

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